Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report

Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report

Blog Article

Background: Scrub typhus is caused by Orientia tsutsugamushi.Clinical manifestations include fever, rash, eschar at the bite site, and other non-specific flu-like symptoms.The eschar is a dark, scab-like area at the bite site, and is the typical lesions that prompts a diagnosis of O.

tsutsugamushi.Without eschar lesions, it is difficult to identify scrub typhus.However, metagenomic next-generation sequencing (mNGS) can moondrop quarks be used to identify infections, and this novel method may help improve clinical diagnosis.

Case presentation: Here, we report a case of scrub typhus in a 51-year-old woman who presented to the amina muaddi scarpe trasparenti emergency department with a week-long fever from an unknown cause.We used mNGS to search for an infectious etiology, and the mNGS suggested O.tsutsugamushi, which was unexpectedly detected.

Discussion and conclusion: This study suggests that mNGS may be a useful diagnostic tool to identify clinical, causative pathogens in fever, particular ones with atypical features.Keywords: Next-generation sequencing, Orientia tsutsugamushi, Fever, Eschars.